Immobile IP3 Receptor Clusters: Building Blocks for IP3-Evoked Ca2+ Signals
نویسندگان
چکیده
منابع مشابه
ATP inhibits IP3-evoked Ca2+ Release in Smooth Muscle
8 9 10 11 12 D. MacMillan*, C. Kennedy & J.G. McCarron 13 14 15 Strathclyde Institute of Pharmacy and Biomedical Sciences, 16 University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK 17 18 19 20 21
متن کاملBuffer kinetics shape the spatiotemporal patterns of IP3-evoked Ca2+ signals.
Ca2+ liberation through inositol 1,4,5-trisphosphate receptors (IP3Rs) plays a universal role in cell regulation, and specificity of cell signalling is achieved through the spatiotemporal patterning of Ca2+ signals. IP3Rs display Ca2+-induced Ca2+ release (CICR), but are grouped in clusters so that regenerative Ca2+ signals may remain localized to individual clusters, or propagate globally betw...
متن کاملTemperature dependence of IP3-mediated local and global Ca2+ signals.
We examined the effect of temperature (12-40°C) on local and global Ca2+ signals mediated by inositol trisphosphate receptor/channels (IP3R) in human neuroblastoma (SH-SY5Y) cells. The amplitudes and spatial spread of local signals arising from single IP3R (blips) and clusters of IP3R (puffs) showed little temperature dependence, whereas their kinetics (durations and latencies) were markedly ac...
متن کاملEndogenous signalling pathways and caged IP3 evoke Ca2+ puffs at the same abundant immobile intracellular sites
The building blocks of intracellular Ca2+ signals evoked by inositol 1,4,5-trisphosphate receptors (IP3Rs) are Ca2+ puffs, transient focal increases in Ca2+ concentration that reflect the opening of small clusters of IP3Rs. We use total internal reflection fluorescence microscopy and automated analyses to detect Ca2+ puffs evoked by photolysis of caged IP3 or activation of endogenous muscarinic...
متن کاملIn smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin.
Ca2+ release from the sarcoplasmic reticulum (SR) by the IP3 receptors (IP3Rs) crucially regulates diverse cell signalling processes from reproduction to apoptosis. Release from the IP3R may be modulated by endogenous proteins associated with the receptor, such as the 12 kDa FK506-binding protein (FKBP12), either directly or indirectly by inhibition of the phosphatase calcineurin. Here, we repo...
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ژورنال
عنوان ژورنال: Messenger
سال: 2018
ISSN: 2167-955X
DOI: 10.1166/msr.2018.1074